MICROBIOLOGICAL STUDIES WITH THIOCTIC ACID ANALOGUES II
نویسندگان
چکیده
منابع مشابه
Microbiological studies with thioctic acid analogues. II. Enzymatic evidence for interference with acetyl transfer by 6-ethyl-8-mercaptooctanoic acid.
6-Ethyl-8-mercaptooctanoic acid, which bears a close chemical relationship to two functional forms of thioctic acid, 6,8-dimercaptooetanoic acid and 6-S-acetyl-6,8-dimercaptooetanoic acid, was found to be toxic for the growth of several microorganisms (Broquist and Stiffey, 1958). These effects were not nullified by thioctic acid, but were reversed competitively by a number of fatty acids inclu...
متن کاملMicrobiological studies with thioctic acid analogues. I. Inhibitory effects of 6-ethyl-8-mercaptooctanoic acid and related thioctic acid analogues for growth of microorganisms.
Present knowledge of the metabolic role of thioctic acid (lipoic acid) is derived almost exclusively from studies of bacterial enzyme systems, although it may well have similar functions in higher plants and animals. A number of microorganisms are known which have an absolute growth requirement for thioctic acid but higher animals do not seem to require preformed thioctic acid for growth. If ef...
متن کاملRemoval of thioctic acid from enzymes.
The r81e of thioctic acid in t’he oxidative decarboxylation of or-keto acids is now well established (1, 2). This was accomplished largely by studies with microbial cells grown essentially free of the cofactor. In some instances (2) it has been possible t,o separate the coenzyme from microbial enzymes involved in t,hioctic acid metabolism by extensive purification procedures. Although tjhe dire...
متن کاملMetabolism of thioctic acid in algae.
Thioctic acid labeled with sulfur-35 has been p repa red and i t s metabol ism b y algae has been studied. It i s converted by the algae into a number of f o r m s , all of which upon hydrolysis yield either the disulfide o r i t s sulfoxide. One of these constituted the major portion of the labeled ma te r i a l in the chlorop1;~sts . Aerobic metabolism for some minutes i s required to produce...
متن کاملThioctic Acid: Physics, Chemistry, and Biology
This paper consti tutes a review of the exper imenta l events that l ed o u r l abo ra to ry to focus i t s attention on thioctic acid , a d i scuss ion of some of the pu re ly chemica l and physical p roper t ies of thioctic acid that this awakened i n t e r e s t p rompted us to invest igate , and a br ief descr ip t ion of some of o u r recen t biological investigations with thioctic acid.
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1958
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.76.6.651-657.1958